Click here for Lexiscan® (regadenoson) injection Full Prescribing Information
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Lexiscan is a pharmacologic stress agent indicated for radionuclide myocardial perfusion
imaging (MPI) in patients unable to undergo adequate exercise stress.
IMPORTANT SAFETY INFORMATION
Do not administer Lexiscan to patients with second- or third-degree AV block or sinus node
dysfunction unless these patients have a functioning artificial pacemaker.
WARNINGS AND PRECAUTIONS
Fatal and nonfatal myocardial infarction, ventricular arrhythmias, and cardiac arrest have
occurred following Lexiscan injection. Avoid use in patients with symptoms or signs of acute
myocardial ischemia, for example unstable angina or cardiovascular instability; these patients
may be at greater risk of serious cardiovascular reactions to Lexiscan. Cardiac resuscitation
equipment and trained staff should be available before administering Lexiscan. If serious
reactions to Lexiscan occur, consider the use of aminophylline, an adenosine antagonist, to
shorten the duration of increased coronary blood flow induced by Lexiscan.
Sinoatrial and Atrioventricular Nodal Block
Adenosine receptor agonists, including Lexiscan, can depress the SA and AV nodes and may
cause first-, second-, or third-degree AV block, or sinus bradycardia requiring intervention. In
postmarketing experience, heart block (including third degree), and asystole within minutes of
Lexiscan administration have occurred.
Atrial Fibrillation/Atrial Flutter
New-onset or recurrent atrial fibrillation with rapid ventricular response and atrial flutter have
been reported following Lexiscan injection.
Hypersensitivity, Including Anaphylaxis
Anaphylaxis, angioedema, cardiac or respiratory arrest, respiratory distress, decreased oxygen
saturation, hypotension, throat tightness, urticaria and rashes have occurred. In clinical trials,
hypersensitivity reactions were reported in fewer than 1 percent of patients.
Adenosine receptor agonists, including Lexiscan, induce arterial vasodilation and hypotension.
The risk of serious hypotension may be higher in patients with autonomic dysfunction,
hypovolemia, left main coronary artery stenosis, stenotic valvular heart disease, pericarditis or
pericardial effusions, or stenotic carotid artery disease with cerebrovascular insufficiency. In
postmarketing experience, transient ischemic attacks, seizures and syncope have been